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Based on the available information, muscle symptoms that may require adjustment of Lipitor (atorvastatin) dosage include muscle pain, weakness, or tenderness, which could be indicative of a serious side effect called rhabdomyolysis [1]. This condition is characterized by the breakdown of muscle fibers, leading to the release of muscle fiber contents, such as myoglobin, into the bloodstream. Elevated levels of myoglobin can cause kidney damage and other complications [1].

The risk of rhabdomyolysis increases when atorvastatin is used in combination with certain medications, such as fibrates, niacin, or cyclosporine [1]. Additionally, factors such as age, renal function, and genetic predisposition may also contribute to the risk [1].

Healthcare professionals should consider dose adjustment or alternative treatment options in patients who experience muscle symptoms while taking Lipitor [1]. Patients should be advised to seek medical attention if they experience unexplained muscle pain, tenderness, or weakness, particularly if accompanied by fever or dark-colored urine [1].

It is important to note that the information provided is based on the available sources and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult with their healthcare provider regarding any questions or concerns about their medications and potential side effects.

Sources:

1. DrugPatentWatch.com. (n.d.). Atorvastatin (Lipitor): Side effects, dosage, and interactions. Retrieved from <https://www.drugpatentwatch.com/drugs/atorvastatin>