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High-dose Ativan, the brand name for lorazepam, can be risky due to several factors. Ativan is a benzodiazepine, a class of drugs commonly used to treat anxiety disorders, insomnia, and seizures. However, when used in high doses, it can lead to serious side effects and potential health risks.
Firstly, high-dose Ativan can lead to severe sedation and drowsiness, impairing cognitive functions, motor skills, and judgment [1]. This can increase the risk of accidents, injuries, and falls, particularly in older adults.
Secondly, long-term use of high-dose Ativan can lead to physical dependence and tolerance [1]. This means that the body adapts to the presence of the drug, requiring higher doses to achieve the same effect. Abruptly stopping the drug can result in withdrawal symptoms, including seizures, anxiety, and insomnia.
Thirdly, high-dose Ativan can suppress respiratory function, leading to respiratory depression and, in severe cases, respiratory failure [2]. This risk is particularly high in individuals with pre-existing respiratory conditions or those taking other respiratory depressants, such as opioids.
Lastly, high-dose Ativan can cause cognitive impairment, including memory loss and confusion [1]. This can affect an individual's ability to perform daily tasks and make decisions, increasing the risk of accidents and injuries.
In conclusion, high-dose Ativan can be risky due to its potential to cause severe sedation, physical dependence, respiratory depression, and cognitive impairment. It is essential to follow the prescribed dosage and consult a healthcare provider before increasing the dose.
Sources:
[1] "Lorazepam." MedlinePlus, U.S. National Library of Medicine, 15 Feb. 2022, medlineplus.gov/druginfo/meds/a682035.html.
[2] "Lorazepam (Oral Route) Side Effects." Mayo Clinic, Mayo Foundation for Medical Education and Research, 1 Jan. 2022, mayoclinic.org/drugs-supplements/lorazepam-oral-route/side-effects/drg-20063023.
[3] "Lorazepam (Ativan) Drug Patent Expiration Dates." DrugPatentWatch, drugpatentwatch.com/drug/lorazepam_ativan.