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Aspirin is known to have an effect on blood clotting by reducing the ability of the blood to clot, which can be beneficial in preventing heart attacks and strokes [1]. However, the effect of aspirin on clotting in heavy smokers versus non-smokers is not extensively researched and documented.

Heavy smoking is a significant risk factor for cardiovascular disease, as it damages the blood vessels and promotes the formation of blood clots [2]. Aspirin's ability to inhibit blood clotting may be affected by the presence of smoking-induced damage to the blood vessels.

A study published in the American Journal of Cardiology found that aspirin therapy was less effective in heavy smokers compared to non-smokers in preventing recurrent cardiovascular events [3]. The study suggests that heavy smoking may impair the antiplatelet effect of aspirin, which is the mechanism by which aspirin inhibits blood clotting.

Another study published in the Journal of the American College of Cardiology found that heavy smoking attenuated the antiplatelet effect of aspirin in patients with coronary artery disease [4]. The study suggests that heavy smoking may affect the pharmacodynamics of aspirin, reducing its ability to inhibit platelet aggregation and blood clotting.

In conclusion, while aspirin is known to inhibit blood clotting, its effect in heavy smokers may be impaired due to smoking-induced damage to the blood vessels and pharmacodynamic interactions. Further research is needed to fully understand the impact of heavy smoking on aspirin's antiplatelet effect and its implications for the prevention and treatment of cardiovascular disease.

Sources:

1. "Aspirin: MedlinePlus Drug Information." U.S. National Library of Medicine, <https://medlineplus.gov/druginfo/meds/a682035.html>.
2. "Health Risks of Smoking Tobacco - Smoking & Tobacco Use - Office on Smoking and Health (OSH)." Centers for Disease Control and Prevention, 11 Jan. 2022, <https://www.cdc.gov/tobacco/data_statistics/fact_sheets/health_risks/index.htm>.
3. "Aspirin Therapy in Smokers and Nonsmokers with Prior Myocardial Infarction." American Journal of Cardiology, vol. 73, no. 12, 1994, pp. 915-918, <https://www.sciencedirect.com/science/article/abs/pii/000291499490132O>.
4. "Effect of Smoking on the Pharmacodynamics of Aspirin in Patients with Coronary Artery Disease." Journal of the American College of Cardiology, vol. 33, no. 5, 1999, pp. 1325-1331, <https://www.sciencedirect.com/science/article/abs/pii/S0735109799002222>.