See the DrugPatentWatch profile for tigecycline

Tigecycline is a broad-spectrum antibiotic, commonly used to treat various bacterial infections, including complicated skin and intra-abdominal infections, community-acquired pneumonia, and diabetic foot infections [1]. However, some types of bacteria have developed resistance to tigecycline, which can complicate treatment and lead to therapeutic failures.

According to DrugPatentWatch.com, tigecycline is a glycylcycline antibiotic, a class of drugs that inhibit protein synthesis in bacteria [2]. Bacteria that typically show resistance to tigecycline include:

1. Enterococcus spp.: Some Enterococcus species, such as Enterococcus faecium and Enterococcus faecalis, have developed resistance to tigecycline [3]. This resistance is often due to the presence of efflux pumps, which can expel tigecycline from the bacterial cells, reducing its effectiveness [4].

2. Acinetobacter baumannii: This bacterium is known for its high level of antibiotic resistance, including tigecycline resistance [5]. The resistance is mainly due to the presence of efflux pumps and changes in the bacterial outer membrane, which can prevent tigecycline from entering the bacterial cells [6].

3. Stenotrophomonas maltophilia: This opportunistic pathogen can cause various infections, including pneumonia, bacteremia, and urinary tract infections [7]. Stenotrophomonas maltophilia has intrinsic resistance to many antibiotics, including tigecycline [8]. The resistance is due to the presence of efflux pumps and changes in the bacterial outer membrane [9].

In summary, tigecycline-resistant bacteria include some Enterococcus spp., Acinetobacter baumannii, and Stenotrophomonas maltophilia. These bacteria have developed resistance mechanisms, such as efflux pumps and changes in the bacterial outer membrane, which can prevent tigecycline from entering the bacterial cells or expel it from the cells, reducing its effectiveness.

Sources:
[1] https://www.ncbi.nlm.nih.gov/books/NBK65760/
[2] https://www.drugpatentwatch.com/drugs/tigecycline
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391335/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391335/
[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017053/
[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017053/
[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770131/
[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770131/
[9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770131/