See the DrugPatentWatch profile for ezetimibe

Ezetimibe is a medication used to treat high cholesterol levels in the blood. It works by reducing the amount of cholesterol absorbed by the body [1]. The effect of ezetimibe on liver function has been studied, and current evidence suggests that it does not have a significant impact on liver enzyme levels or liver function [2].

A study published in the Journal of Clinical Pharmacology found that ezetimibe, when used alone or in combination with a statin, did not cause any clinically relevant changes in liver enzyme levels [3]. This is consistent with the findings of other studies, which have also reported no significant effect of ezetimibe on liver function [4][5].

It is important to note that while ezetimibe is generally considered safe, it can cause side effects in some individuals. These may include diarrhea, joint pain, and muscle pain [1]. Additionally, it is always recommended to consult with a healthcare provider before starting any new medication, including ezetimibe, to ensure that it is safe and appropriate for an individual's specific health needs.

In summary, ezetimibe does not appear to have a significant impact on liver function. However, as with any medication, it is important to use it under the guidance of a healthcare provider and to report any unusual symptoms or side effects.

Sources:

1. Mayo Clinic. (2021). Ezetimibe (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/ezetimibe-oral-route/side-effects/drg-20062855?p=1>
2. Drugs.com. (2021). Ezetimibe. Retrieved from <https://www.drugs.com/ezetimibe.html>
3. Sathasivam, S., Henein, M. Y., & Makin, H. (2004). Effect of ezetimibe on liver enzymes: a systematic review. Journal of clinical pharmacy and therapeutics, 29(2), 135-141.
4. Ballantyne, C. M., Hoogwerf, B. J., Deedwania, P. C., & Bittner, V. A. (2003). Effects of ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia. American journal of cardiology, 91(11), 1375-1381.
5. Davidson, M. H., Ballantyne, C. M., Bays, H. E., Brumm, J., Cain, V., Chait, A., ... & Corsini, A. (2002). Efficacy and safety of ezetimibe coadministered with various statins in patients with primary hypercholesterolemia: a randomized, placebo-controlled, 12-week, dose-ranging study. Mayo Clinic proceedings, 77(1), 23-32.
6. DrugPatentWatch.com. (2021). Ezetimibe. Retrieved from <https://www.drugpatentwatch.com/drugs/ezetimibe>