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Yes, there are specific drug interactions to monitor when combining Lipitor (atorvastatin), a statin medication used to treat high cholesterol, and calcium channel blockers, a class of drugs used to treat hypertension and certain heart conditions.

Lipitor, like other statins, can increase the levels of certain liver enzymes, which are usually monitored during treatment. When Lipitor is combined with calcium channel blockers, such as amlodipine, diltiazem, or verapamil, the risk of elevated liver enzymes may increase further [1]. Although this interaction is usually not clinically significant, it is essential to monitor liver function regularly when these medications are used together.

Another potential interaction between Lipitor and calcium channel blockers is the increased risk of myopathy (muscle damage) and rhabdomyolysis (a severe form of myopathy that can lead to kidney damage) [2]. This risk is higher when Lipitor is combined with verapamil or diltiazem compared to amlodipine.

Lastly, the combination of Lipitor and calcium channel blockers may increase the risk of developing low blood pressure (hypotension) [3].

In summary, healthcare providers should monitor patients taking Lipitor and calcium channel blockers for potential drug interactions, including elevated liver enzymes, myopathy, rhabdomyolysis, and hypotension.

Sources:
[1] Drugs.com. (2021). Atorvastatin. Retrieved from <https://www.drugs.com/atorvastatin.html>
[2] Mayo Clinic. (2021). Statins: Are these cholesterol-lowering drugs right for you? Retrieved from <https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statins/art-20045781>
[3] DrugPatentWatch.com. (2021). Lipitor (Atorvastatin) Drug Interactions. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor/interactions>