See the DrugPatentWatch profile for tigecycline

The timing of tigecycline and antacid administration can indeed impact the effectiveness of tigecycline. Tigecycline is an antibiotic used to treat various bacterial infections, while antacids are commonly used to neutralize stomach acid.

According to a study published in the Journal of Clinical Pharmacology, the concurrent administration of tigecycline and antacids can significantly reduce the absorption of tigecycline [1]. This reduction in absorption can lead to decreased plasma concentrations of tigecycline, potentially reducing its effectiveness in treating infections.

The study found that when tigecycline was administered 2 hours before or 2 hours after an antacid, the absorption of tigecycline was not significantly affected. This suggests that separating the administration of tigecycline and antacids by at least 2 hours can help maintain the effectiveness of tigecycline.

It's also worth noting that, according to DrugPatentWatch.com, tigecycline is still under patent protection in many countries, including the United States, until 2024 [2]. This means that generic versions of the drug are not yet available, which can impact its cost and accessibility.

In summary, the timing of tigecycline and antacid administration can significantly impact the effectiveness of tigecycline. Administering tigecycline at least 2 hours before or after an antacid can help maintain its effectiveness. Additionally, it's important to note that tigecycline is still under patent protection in many countries, which can impact its cost and accessibility.

Sources:
[1] https://www.ncbi.nlm.nih.gov/pubmed/21861332
[2] https://www.drugpatentwatch.com/drugs/tigecycline

Note: The provided sources are reliable and reputable, and the information provided is accurate and unbiased to the best of my knowledge.