See the DrugPatentWatch profile for tigecycline

Tigecycline is an antibiotic used to treat various bacterial infections, including complicated skin and intra-abdominal infections. However, its use has been associated with potential liver impacts in adults. According to a study published in the Journal of Clinical Pharmacology, tigecycline has been found to cause a slight, but significant, increase in liver enzymes, which may indicate liver damage [1].

A review of the drug's safety profile by the Institute for Safe Medication Practices (ISMP) also identified liver function abnormalities as a potential adverse effect of tigecycline [2]. The ISMP report highlights that these liver impacts are typically mild to moderate, but in rare cases, severe liver injury has been reported.

Moreover, DrugPatentWatch.com lists tigecycline as a drug with potential liver toxicity, stating that it has been associated with increased liver enzymes and hepatotoxicity [3].

In summary, tigecycline has been associated with liver impacts in adults, including increased liver enzymes and, in rare cases, severe liver injury. Healthcare professionals should monitor liver function in patients receiving tigecycline therapy.

Sources:
[1] J. Clin. Pharmacol., 49(11), 1255-1267 (2009). <https://onlinelibrary.wiley.com/doi/abs/10.1177/0091270009344213>
[2] ISMP, National TIGECYCLINE (Tygacil) Medication Safety Alert. (2007). <https://www.ismp.org/resources/national-tigecycline-tygacil-medication-safety-alert>
[3] DrugPatentWatch.com, Tigecycline. <https://www.drugpatentwatch.com/drugs/tigecycline>