See the DrugPatentWatch profile for warfarin

Based on the information available, it is possible to combine Lipator (atorvastatin) and warfarin, but it is crucial to do so under the close supervision of a healthcare provider.

Lipator is a medication used to lower cholesterol levels, while warfarin is an anticoagulant that prevents blood clots. Both medications are metabolized in the liver, and combining them may increase the risk of side effects, particularly bleeding [1].

A study published in the Journal of Clinical Pharmacy and Therapeutics found that co-administration of atorvastatin and warfarin resulted in a slight increase in international normalized ratio (INR), a measure of blood clotting time [2]. However, the clinical significance of this finding is unclear, and further research is needed to determine the overall safety and efficacy of combining these medications.

It is essential to monitor INR levels closely when combining Lipator and warfarin, and healthcare providers may need to adjust warfarin dosages accordingly [3]. Patients should also inform their healthcare providers of any changes in medication or supplement use, as these factors can affect INR levels.

In summary, while it is possible to combine Lipator and warfarin, it is crucial to do so under the close supervision of a healthcare provider. Close monitoring of INR levels and potential dose adjustments may be necessary.

Sources:

1. Mayo Clinic. (2021). Atorvastatin (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/precautions/drg-20067051>.
2. Lee, J. Y., Lee, S. Y., & Kim, Y. H. (2012). Effects of atorvastatin on the pharmacodynamics and pharmacokinetics of warfarin in healthy subjects. Journal of Clinical Pharmacy and Therapeutics, 37(3), 275-281.
3. Drugs.com. (2021). Warfarin and Atorvastatin Interaction. Retrieved from <https://www.drugs.com/drug-interactions/warfarin-with-atorvastatin-392-1313-1311-0/>.
4. DrugPatentWatch.com. (2021). Atorvastatin. Retrieved from <https://www.drugpatentwatch.com/drugs/atorvastatin>.