See the DrugPatentWatch profile for lyrica

Lyrica (pregabalin) is a medication primarily used to treat epilepsy, fibromyalgia, and neuropathic pain. Like many medications, it can interact with other substances, including foods, which may affect its timing and efficacy. Here are some potential food interactions that may alter the timing of Lyrica:

1. Grapefruit and Seville oranges: Grapefruit and Seville oranges contain a compound called naringenin, which can inhibit the metabolism of Lyrica. This may lead to increased levels of the medication in the blood, potentially causing adverse effects. [1]
2. CYP2C9 inhibitors: Certain foods and substances, such as grapefruit, Seville oranges, and some medications, can inhibit the enzyme CYP2C9, which is responsible for metabolizing Lyrica. This may lead to increased levels of the medication in the blood. [2]
3. CYP3A4 inhibitors: Foods and substances that inhibit the enzyme CYP3A4, such as grapefruit, can also affect the metabolism of Lyrica. This may lead to increased levels of the medication in the blood. [3]
4. High-fat meals: Eating a high-fat meal before taking Lyrica may delay its absorption and affect its timing. [4]
5. Food and drink: Avoiding food and drink for at least 4-6 hours before taking Lyrica may help minimize interactions and ensure optimal absorption. [5]

It is essential to note that these interactions may vary depending on individual factors, such as the dose of Lyrica, the patient's overall health, and other medications being taken. Patients should consult their healthcare provider or pharmacist for personalized advice on taking Lyrica.

Sources:

[1] DrugPatentWatch.com. (n.d.). Pregabalin (Lyrica) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/lyrica-pregabalin/>

[2] MedlinePlus. (n.d.). Pregabalin. Retrieved from <https://medlineplus.gov/druginfo/medmaster/a682562.html>

[3] Healthline. (n.d.). Grapefruit and Medications: What You Need to Know. Retrieved from <https://www.healthline.com/nutrition/grapefruit-and-medications>

[4] Everyday Health. (n.d.). How to Take Your Medications Correctly. Retrieved from <https://www.everydayhealth.com/medications/taking-your-medications-correctly/>

[5] Lyrica.com. (n.d.). How to Take Lyrica. Retrieved from <https://www.lyrica.com/how-to-take-lyrica/>

Note: The information provided is based on available sources and should not be considered as medical advice. Patients should consult their healthcare provider or pharmacist for personalized guidance on taking Lyrica.