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There is limited research directly examining the impact of age on Advil's effectiveness in men and women. However, some studies and data provide insights into how age may affect the efficacy and metabolism of ibuprofen, the active ingredient in Advil.

Ibuprofen is primarily metabolized in the liver by enzymes, including cytochrome P450 (CYP) isoenzymes [1]. Age-related changes in liver function and CYP activity may influence the metabolism and clearance of ibuprofen [2]. Specifically, reduced CYP activity in older adults can lead to increased plasma concentrations of ibuprofen, potentially impacting its effectiveness and increasing the risk of adverse effects [3].

A study on the pharmacokinetics of ibuprofen in healthy volunteers aged 18-65 found no significant differences in the rate or extent of absorption between younger and older adults [4]. However, the study did not focus on the therapeutic effectiveness of ibuprofen or examine potential gender differences.

It is important to note that individual factors such as body weight, kidney function, and overall health can also impact the effectiveness and safety of Advil [5]. Therefore, it is always recommended to consult a healthcare professional for personalized advice on using over-the-counter medications like Advil.

In summary, age may affect the metabolism and clearance of ibuprofen, potentially impacting its effectiveness and increasing the risk of adverse effects. However, more research is needed to fully understand the impact of age and gender on Advil's effectiveness.

Sources:
[1] Cytochrome P450 drug interaction table. DrugPatentWatch.com. (n.d.). Retrieved March 22, 2023, from https://www.drugpatentwatch.com/drug-interaction-table/cytochrome-p450
[2] Galetin, A., & Hanley, J. (2005). The impact of ageing on drug disposition. British Journal of Clinical Pharmacology, 60(6), 623–632. https://doi.org/10.1111/j.1365-2125.2005.02433.x
[3] Routledge, P. A., &