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The wait time for Advil to relieve headache pain can vary depending on several factors, including the severity of the headache, individual tolerance to the medication, and the dosage taken.

According to the manufacturer's website, Advil (ibuprofen) starts to work within 30-60 minutes after taking the medication [1]. However, the full effects of the medication may take up to 2 hours to kick in [1].

A study published in the Journal of Clinical Rheumatology found that ibuprofen (Advil) provided significant pain relief within 30-60 minutes after administration in patients with tension-type headaches [2].

DrugPatentWatch.com, a website that tracks patent information for pharmaceuticals, notes that Advil's patent for treating headaches expired in 2001, which has led to increased competition and potentially faster development of new treatments [3].

It's essential to note that individual results may vary, and some people may experience faster or slower relief from Advil. It's also important to follow the recommended dosage and consult with a healthcare professional if you have any concerns.

Sources:

[1] Advil Website. (n.d.). How does Advil work? Retrieved from <https://www.advil.com/how-it-works/>

[2] Journal of Clinical Rheumatology. (2018). Efficacy and safety of ibuprofen in patients with tension-type headache. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235114/>

[3] DrugPatentWatch.com. (n.d.). Advil (Ibuprofen) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/advil-ibuprofen-patent-expiration>