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According to the information available, it is generally considered safe to take Advil (ibuprofen) on an empty stomach, including before bedtime. However, it is important to note that taking Advil on an empty stomach may increase the likelihood of experiencing adverse effects such as stomach upset or ulcers, especially with long-term use [1].

It is always recommended to follow the instructions provided by the manufacturer or a healthcare professional. The label of Advil states that it can be taken with or without food, but if stomach upset occurs, it is advised to take it with food [2].

It is also important to be aware of the correct dosage and not to exceed the recommended amount. Overdosing on Advil can lead to serious health complications [3].

In conclusion, it is generally safe to take Advil on an empty stomach before bedtime, but it may increase the risk of stomach upset. It is always best to follow the instructions provided and to consult a healthcare professional if there are any concerns.

Sources:

1. <https://www.webmd.com/ibuprofen-oral/ibuprofen-oral-side-effects#1>
2. <https://www.drugs.com/advil.html>
3. <https://www.drugpatentwatch.com/ibuprofen>