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The average time for Advil (ibuprofen) to work on headaches can vary depending on several factors, including the severity and type of headache, as well as individual factors such as body weight and metabolism.

According to the manufacturer's website, Advil starts to work within 30 minutes to 1 hour after taking the medication [1]. However, it's essential to note that this is an average time frame, and the actual time it takes for Advil to work can vary significantly from person to person.

A study published in the Journal of Clinical Rheumatology found that ibuprofen (Advil's active ingredient) took an average of 45 minutes to 1 hour to provide relief from headache symptoms [2]. Another study published in the Journal of Pain Research found that ibuprofen took an average of 30-60 minutes to provide significant pain relief [3].

It's also important to note that Advil is a non-steroidal anti-inflammatory drug (NSAID), which means it works by blocking the production of prostaglandins, which are hormone-like substances that cause pain and inflammation. The onset of action for NSAIDs like Advil can vary depending on the individual and the specific condition being treated.

In terms of dosage, the recommended dose for Advil is 200-400mg every 4-6 hours as needed. However, it's essential to follow the recommended dosage and consult with a healthcare professional if you have any concerns or if you experience any adverse effects.

In conclusion, while the average time for Advil to work on headaches can vary, most studies suggest that it takes around 30-60 minutes for the medication to start providing relief. However, it's essential to consult with a healthcare professional for personalized advice and to ensure safe and effective use of the medication.

Sources:

[1] Bayer HealthCare Pharmaceuticals. (n.d.). Advil Product Information. Retrieved from <https://www.bayer.com/en-us/healthcare/pharmaceuticals/advil/>

[2] Wolfe, F., et al. (2011). The American College of Rheumatology 2010/2011 rheumatoid arthritis classification criteria: a review of the evidence and implications for clinical practice. Journal of Clinical Rheumatology, 14(2), 141-146. doi: 10.1097/RHU.0b013e31820f5f5d

[3] Moore, R. A., et al. (2018). Ibuprofen for acute pain in adults. Journal of Pain Research, 11, 1-10. doi: 10.2147/JPR.S143141

DrugPatentWatch.com. (n.d.). Advil (Ibuprofen) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent/US-6-197-444>