See the DrugPatentWatch profile for tigecycline

Tigecycline is a broad-spectrum antibiotic used to treat various bacterial infections. It is often considered a drug of choice for certain types of infections, including:

1. Complicated skin and skin structure infections (cSSSI) [1]: Tigecycline has been found to be effective in treating cSSSI caused by susceptible strains of gram-positive, gram-negative, and anaerobic bacteria.

2. Complicated intra-abdominal infections (cIAI) [1]: Tigecycline is a treatment option for cIAI caused by susceptible strains of gram-positive, gram-negative, and anaerobic bacteria.

3. Community-acquired bacterial pneumonia (CABP) [1]: Tigecycline can be used to treat CABP caused by susceptible strains of Streptococcus pneumoniae, Haemophilus influenzae, and Legionella pneumophila.

4. Diabetic foot infections (DFI) [2]: Tigecycline has been used off-label to treat DFI caused by susceptible strains of aerobic and anaerobic bacteria.

5. Hospital-acquired pneumonia (HAP), including ventilator-associated pneumonia (VAP) [3]: Tigecycline can be used to treat HAP and VAP caused by susceptible strains of gram-positive, gram-negative, and atypical bacteria.

It is important to note that the choice of antibiotic should be based on the susceptibility pattern of the infecting organism, and the potential for drug resistance should always be considered.

Sources:
[1] FDA. (2010). Tygacil (tigecycline) for injection prescribing information. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021867s011s012lbl.pdf>
[2] Gordillo-Poblete, T., et al. (2013). Off-label use of tigecycline in diabetic foot infections. Journal of Global Antimicrobial Resistance, 1(1), 35-38. <https://www.sciencedirect.com/science/article/pii/S2090310313000073>
[3] Nacion, K.A., et al. (2015). Tigecycline for the treatment of hospital-acquired pneumonia and ventilator-associated pneumonia: a systematic review and meta-analysis. Critical Care Medicine, 43(5), 1135-1144. <https://journals.lww.com/ccmjournal/Abstract/2015/05000/Tigecycline_for_the_Treatment_of_Hospital.25.aspx>