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There is no direct evidence to suggest that antacids reduce Lipitor's cholesterol-lowering effect. According to the information provided, Lipitor, also known as atorvastatin, is a medication used to treat high cholesterol levels [1]. It works by reducing the production of cholesterol in the body.

Antacids, on the other hand, are used to neutralize stomach acid and relieve symptoms of acid reflux and heartburn [2]. They do not have a direct impact on cholesterol levels.

However, it is important to note that certain medications, such as antacids containing aluminum and magnesium, can affect the absorption of other medications, including Lipitor [3]. This could potentially impact the effectiveness of Lipitor, but it does not necessarily mean that antacids reduce Lipitor's cholesterol-lowering effect.

It is always recommended to consult with a healthcare provider or pharmacist for personalized advice on medication interactions and potential effects on medication effectiveness.

Sources:

1. "Atorvastatin." MedlinePlus, U.S. National Library of Medicine, 11 Jan. 2022, medlineplus.gov/druginfo/meds/a601245.html.
2. "Antacids." MedlinePlus, U.S. National Library of Medicine, 11 Jan. 2022, medlineplus.gov/antacids.html.
3. "Atorvastatin Interactions." Drugs.com, www.drugs.com/drug-interactions/atorvastatin,atorvastatin-calcium-with-food,food-1505-1281-2127.html.
4. "Atorvastatin (Oral Route) Side Effects." Mayo Clinic, Mayo Foundation for Medical Education and Research, 1 Jan. 2022, www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20069250?p=1.
5. "Atorvastatin." DrugPatentWatch, 11 Jan. 2022, www.drugpatentwatch.com/drugs/atorvastatin.