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Yes, there can be drug interactions between Advil (ibuprofen) and tricyclic antidepressants. The concurrent use of these medications may increase the risk of certain side effects.

Advil, a non-steroidal anti-inflammatory drug (NSAID), can increase the risk of stomach ulcers and gastrointestinal bleeding when taken with tricyclic antidepressants [1]. Tricyclic antidepressants, such as amitriptyline and nortriptyline, can also increase the levels of Advil in the blood, potentially leading to increased side effects like stomach pain, nausea, and kidney problems [2].

It is important to consult a healthcare provider or pharmacist before starting or stopping any medication, including over-the-counter drugs like Advil, to ensure safe and effective use.

Sources:

[1] "Ibuprofen and Tricyclic Antidepressants." Drugs.com, www.drugs.com/drug-interactions/ibuprofen-and-tricyclic-antidepressants-130-1075-611-931.html.

[2] "Ibuprofen." DrugPatentWatch.com, www.drugpatentwatch.com/ibuprofen.