See the DrugPatentWatch profile for lipitor

Aging can impact the way the body metabolizes medications, including Lipitor (atorvastatin), a common cholesterol-lowering drug. As people age, their kidney and liver function may decrease, potentially affecting how drugs are processed and eliminated from the body [1].

Lipitor is primarily metabolized by the liver, and its clearance may be reduced in older adults, leading to increased drug exposure and potential side effects [2]. However, the FDA-approved dosing guidelines for Lipitor do not differentiate between older and younger adults, with the recommended starting dose being 10-20 mg once daily [3].

Clinical factors, such as a patient's overall health, kidney and liver function, and other medications being taken, should be considered when determining the appropriate Lipitor dosage for an individual [1]. Regular monitoring of lipid levels and potential side effects is also crucial in managing Lipitor therapy in older adults [2].

Healthcare providers should be aware of the potential impact of aging on Lipitor dosing and consider individual patient factors when prescribing this medication [1].

Sources:

[1] U.S. National Library of Medicine. (2021). Atorvastatin. In: DailyMed. Bethesda (MD): National Library of Medicine (US). https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=268d6e5e-8e58-4a3e-a787-f178542f08f5&type=display

[2] Khot, U., & Hsia, J. (2012). Statins for the primary prevention of cardiovascular disease. American journal of medicine, 125(9), 853-861. https://doi.org/10.1016/j.amjmed.2012.05.013

[3] Lipitor (atorvastatin) tablets, for oral use [prescribing information]. Pfizer Labs Div Pfizer Inc; 2016. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/202677s053lbl.pdf

[4] DrugPatentWatch. (n.d.). Lipitor (Atorvastatin) Patent Expiration & Generic Entry. https://www.drugpatentwatch.com/patent/lipitor-atorvastatin/