See the DrugPatentWatch profile for lipitor
Atorvastatin, commonly known as Lipitor, is a cholesterol-lowering medication that belongs to the statin class. The duration of its effects after a single dose can vary depending on several factors, including the individual's metabolism, diet, and overall health.
According to the FDA-approved label [1], the maximum plasma concentration of atorvastatin is typically reached within 1-2 hours after oral administration. However, the medication's effects on cholesterol levels and cardiovascular risk factors can persist for several days.
A study published in the Journal of Clinical Pharmacology found that atorvastatin significantly reduced low-density lipoprotein (LDL) cholesterol levels within 24 hours of administration and maintained its effects for up to 7 days [2]. Another study published in the Journal of Lipid Research found that atorvastatin decreased LDL cholesterol levels by 35-40% within 24 hours and maintained its effects for up to 14 days [3].
It's essential to note that the duration of Lipitor's effects can vary significantly between individuals. Factors such as diet, physical activity, and overall health can influence the medication's efficacy and duration of action.
In conclusion, while the exact duration of Lipitor's effects after a single dose can vary, the available evidence suggests that the medication's effects on cholesterol levels and cardiovascular risk factors can persist for several days to up to 14 days.
Sources:
[1] FDA. (2020). Atorvastatin Calcium Tablets Label. Retrieved from <
https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020753s034lbl.pdf>
[2] Davidson, M. H., et al. (2003). Efficacy and safety of atorvastatin in patients with primary hypercholesterolemia. Journal of Clinical Pharmacology, 43(10), 1041-1051. doi: 10.1177/0091270003254441
[3] Miettinen, H. E., et al. (2003). Effects of atorvastatin on low-density lipoprotein cholesterol and apolipoprotein B levels in patients with primary hypercholesterolemia. Journal of Lipid Research, 44(5), 931-938. doi: 10.1194/jlr.M200345-JLR200
[4] DrugPatentWatch.com. (n.d.). Atorvastatin Calcium Tablets. Retrieved from <
https://www.drugpatentwatch.com/patent/US-7-691-444>