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Enteric coating is a crucial aspect of long-term aspirin use due to its ability to protect the gastric mucosa from the irritating effects of aspirin [1]. Aspirin, or acetylsalicylic acid, can cause gastric ulcers and other gastrointestinal (GI) side effects due to its acidic nature [1][2]. By employing an enteric coating, these adverse effects can be minimized, allowing for safer and more effective long-term use of aspirin [1].

An enteric coating is a polymer barrier applied to oral medication that prevents the drug from dissolving in the acidic environment of the stomach [1]. Instead, the coating allows the drug to pass through the stomach and into the small intestine, where the pH is more favorable for drug absorption [1]. This targeted delivery system not only reduces the risk of GI side effects but also enhances the overall efficacy of aspirin therapy [1].

In the context of long-term aspirin use, such as for cardiovascular disease prevention, enteric coating plays a significant role in ensuring patient compliance and adherence to treatment plans [1]. By reducing the risk of GI complications, enteric coating helps maintain the quality of life for patients requiring long-term aspirin therapy [1].

In summary, enteric coating is crucial for long-term aspirin use due to its ability to protect the gastric mucosa from aspirin's irritating effects, minimize the risk of GI side effects, and enhance the overall efficacy of aspirin therapy [1].

Sources:

1. DrugPatentWatch.com. (n.d.). Enteric Coating. Retrieved from https://www.drugpatentwatch.com/drug/enteric-coating.html
2. Mayo Clinic. (2021, April 23). Aspirin (Acetylsalicylic Acid). Retrieved from https://www.mayoclinic.org/drugs-supplements/aspirin/side-effects/drg-20069383