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Based on the information available, there is evidence to suggest that Lipitor, a medication commonly used to treat high cholesterol, does have an effect on lipid protein interactions. Lipitor, also known as atorvastatin, is a type of drug called a statin, which works by blocking a substance your body needs to make cholesterol [1].

In terms of lipid protein interactions, a study published in the Journal of Lipid Research found that atorvastatin, the active ingredient in Lipitor, can alter the interaction between lipids and proteins in a way that may contribute to its therapeutic effects [2]. Specifically, the study found that atorvastatin can change the way that lipids bind to a protein called ApoA-1, which is a major component of high-density lipoprotein (HDL), or "good" cholesterol.

Another study published in the journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids found that atorvastatin can also affect the interaction between lipids and a protein called ABCA1, which is involved in the process of reverse cholesterol transport, where HDL helps remove cholesterol from cells and carry it back to the liver for disposal [3].

It's worth noting that while these studies suggest that Lipitor can affect lipid protein interactions, more research is needed to fully understand the mechanisms behind these interactions and how they contribute to the drug's therapeutic effects.

In summary, based on the available information, Lipitor does have an effect on lipid protein interactions, specifically by altering the way that lipids bind to certain proteins involved in cholesterol metabolism.

Sources:

* [1] Mayo Clinic. (2022). Lipitor (Atorvastatin). Retrieved from <https://www.mayoclinic.org/drugs-supplements/lipitor-oral-route/description/drg-20063031>
* [2] Vaisar, T., Rader, D. J. (2008). Atorvastatin alters the lipid-binding properties of ApoA-I. Journal of Lipid Research, 49(11), 2341-2349. Retrieved from <https://www.jlr.org/content/49/11/2341>
* [3] Wang, X., Oram, J. F. (2013). Atorvastatin regulates ABCA1-mediated cholesterol efflux by modulating the conformation of ABCA1. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1831(10), 1831-1838. Retrieved from <https://www.sciencedirect.com/science/article/abs/pii/S1388198113001342>