See the DrugPatentWatch profile for acyclovir

Acyclovir is an antiviral medication used to treat and prevent herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections, including cold sores, genital herpes, and shingles [1]. Potential acyclovir dependencies refer to the drugs or substances that may interact with acyclovir, leading to altered effectiveness or side effects.

According to DrugPatentWatch.com, there are several drugs that may interact with acyclovir [2]:

1. Probenecid: This medication, used to treat gout and gouty arthritis, can increase acyclovir levels in the body, potentially leading to increased side effects [2].

2. Tenofovir: A medication used to treat and prevent HIV and Hepatitis B, tenofovir may decrease acyclovir levels in the body, potentially reducing its effectiveness [2].

3. Cimetidine: A medication used to treat and prevent ulcers, cimetidine may increase acyclovir levels in the body, potentially leading to increased side effects [2].

4. Various Antacids: Some antacids, particularly those containing magnesium and aluminum, may decrease acyclovir levels in the body, potentially reducing its effectiveness [2].

It is important to note that this list may not be exhaustive, and other drugs or substances may also interact with acyclovir. Therefore, it is crucial to consult a healthcare provider or pharmacist before starting any new medications or supplements while taking acyclovir [1].

Sources:

[1] Mayo Clinic. (2021). Acyclovir (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/acyclovir-oral-route/side-effects/drg-20062831?p=1>

[2] DrugPatentWatch.com. (2021). Acyclovir Interactions. Retrieved from <https://www.drugpatentwatch.com/drugs/acyclovir/interactions>