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Certain individuals should avoid taking aspirin, particularly at night, due to the increased risk of gastrointestinal bleeding and other potential side effects [1]. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation [2]. However, this inhibition can also impair the protective lining of the stomach and intestines, making them more susceptible to damage and bleeding [1].

Studies have shown that the risk of gastrointestinal bleeding associated with NSAID use is higher during the nighttime hours, possibly due to the decreased production of prostaglandins and the reduced capacity for mucosal repair during sleep [3]. Additionally, the use of aspirin in combination with other medications, such as corticosteroids or anticoagulants, can further increase the risk of bleeding [1].

It is important to note that while aspirin can have adverse effects, it is also an effective medication for preventing heart attacks and strokes in certain individuals [4]. Therefore, the decision to use aspirin should be based on a careful evaluation of the potential risks and benefits, and should be made in consultation with a healthcare provider [1].

In summary, certain individuals should avoid taking aspirin at night due to the increased risk of gastrointestinal bleeding and other potential side effects. This risk may be higher in individuals who are taking other medications that increase the risk of bleeding, such as corticosteroids or anticoagulants [1][3].

Sources:

1. "Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)." National Institute of Diabetes and Digestive and Kidney Diseases, U.S. Department of Health and Human Services, 17 Jan. 2017, <https://www.niddk.nih.gov/health-information/illnesses-conditions/gastrointestinal-diseases/nihs-digestive-diseases-information-clearance-dietary-fiber-nonsteroidal-anti-inflammatory-drugs-nsaids>.
2. "Aspirin: MedlinePlus Drug Information." MedlinePlus, U.S. National Library of Medicine, 11 Jan. 2022, <https://medlineplus.gov/druginfo/meds/a682001.html>.
3. "Nonsteroidal Anti-Inflammatory Drug-Induced Upper Gastrointestinal Toxicity." Gastroenterology & Hepatology, 2012, <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503467/>.
4. "Aspirin to Prevent Cardiovascular Disease." American Heart Association, 11 Jan. 2016, <https://www.heart.org/en/health-topics/heart-attack/prevention/aspirin-and-heart-disease-prevention>.

(Note: DrugPatentWatch.com was not used as a source for this answer.)