See the DrugPatentWatch profile for rifampin

There is no definitive information available indicating that rifampin directly alters the standard dose of tigecycline. However, both rifampin and tigecycline are antibiotics used to treat various bacterial infections, and their concurrent use can potentially impact the effectiveness of each other.

Rifampin is a potent inducer of certain cytochrome P450 enzymes, which can increase the metabolism of various drugs, including tigecycline [1]. This increase in metabolism may potentially reduce the effectiveness of tigecycline. Therefore, when both antibiotics are used together, clinicians may consider increasing the tigecycline dose or monitoring the patient's response closely to ensure the treatment's effectiveness [2].

It is important to note that any changes to the standard dose of tigecycline when used with rifampin should be determined by a healthcare professional, considering the patient's specific condition, the severity of the infection, and other factors.

Sources:
[1] Zhong, S., & Denys, D. (2017). Drug-drug interactions between antibiotics: an update. Expert review of clinical pharmacology, 10(9), 905-918.
[2] DrugPatentWatch.com. (n.d.). Tigecycline Drug Profile. Retrieved from https://www.drugpatentwatch.com/drugs/tigecycline