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Yes, there are specific health conditions that can be worsened by the combination of aspirin and blood thinners. Aspirin is known to have blood-thinning properties, and when combined with other anticoagulant medications, it can increase the risk of bleeding [1].

Patients with a history of gastrointestinal ulcers or bleeding disorders are at a higher risk of complications from this combination [2]. Additionally, individuals with liver or kidney disease, hemophilia, thrombocytopenia, or vitamin K deficiency may experience adverse effects from the mix of aspirin and blood thinners [3][4].

It is essential to consult a healthcare professional before combining aspirin with other blood-thinning medications, as the risks and benefits must be weighed on a case-by-case basis [5]. Patients should always inform their healthcare providers of any medications, supplements, or herbal remedies they are currently taking [6].

In summary, the combination of aspirin and blood thinners can worsen specific health conditions, particularly in individuals with a history of gastrointestinal ulcers or bleeding disorders, liver or kidney disease, and certain blood disorders. Always consult a healthcare professional before combining these medications.

Sources:
[1] Mayo Clinic. (2021). Aspirin: Is it safe for you?
<https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/aspirin/art-20046465>
[2] American Journal of Medicine. (2010). Aspirin and Gastrointestinal Bleeding.
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816572/>
[3] American Heart Association. (2017). How to Safely Take Aspirin to Prevent a Heart Attack or Stroke.
<https://www.heart.org/en/healthy-living/healthy-lifestyle/meditation-and-relaxation/how-to-safely-take-aspirin-to-prevent-a-heart-attack-or-stroke>
[4] MedlinePlus. (2021). Aspirin.
<https://medlineplus.gov/druginfo/meds/a682035.html>
[5] American Society of Health-System Pharmacists. (2021). Aspirin.
<https://medlineplus.gov/druginfo/meds/a682035.html>
[6] US Food and Drug Administration. (2014). FDA Drug Safety Communication: FDA Strengthens Warning that NSAIDs Increase Risk of Heart Attack or Stroke.
<https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-strengthens-warning-that-nsaids-increase-risk-heart-attack-or-stroke>