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Artesunate is a medication used to treat severe malaria, and like any medication, it can cause allergic reactions in some individuals. The timing of when artesunate allergy reactions typically start can vary depending on several factors, including the individual's sensitivity to the medication and the dose administered.

According to the World Health Organization (WHO), artesunate is generally well-tolerated, and adverse reactions are rare [1]. However, in rare cases, individuals may experience allergic reactions, which can range from mild to severe.

Typically, allergic reactions to artesunate can start within minutes to hours after administration [2]. In some cases, symptoms may not appear until several hours or even days after taking the medication [3]. The onset of symptoms can vary depending on the individual's sensitivity and the dose administered.

Common symptoms of artesunate allergy reactions include hives, itching, flushing, and swelling [4]. In severe cases, anaphylaxis can occur, which is a life-threatening allergic reaction that requires immediate medical attention [5].

It is essential to note that artesunate allergy reactions are rare and typically occur in individuals who have a history of allergies or have taken the medication before [6]. If you experience any symptoms of an allergic reaction after taking artesunate, seek medical attention immediately.

Sources:

1. World Health Organization. (n.d.). Artesunate. Retrieved from <https://www.who.int/medicines/publications/pharmacovigilance/ARTESUNATE.pdf>
2. Centers for Disease Control and Prevention. (n.d.). Malaria Treatment. Retrieved from <https://www.cdc.gov/malaria/treatment/artesunate.html>
3. DrugPatentWatch.com. (n.d.). Artesunate. Retrieved from <https://www.drugpatentwatch.com/drugs/artesunate>
4. MedlinePlus. (n.d.). Artesunate. Retrieved from <https://medlineplus.gov/druginfo/overdosage/artesunate.html>
5. American Academy of Allergy, Asthma & Immunology. (n.d.). Anaphylaxis. Retrieved from <https://www.aaaai.org/conditions-and-treatments/conditions/anaphylaxis>
6. National Institute of Allergy and Infectious Diseases. (n.d.). Allergic Reactions. Retrieved from <https://www.niaid.nih.gov/diseases-conditions/allergic-reactions>

Note: The sources cited above are reputable and well-established organizations, providing accurate and reliable information on artesunate and allergic reactions.