See the DrugPatentWatch profile for methotrexate

Yes, methotrexate can interact with certain drugs and potentially lower their effectiveness. Methotrexate is a medication commonly used to treat conditions such as rheumatoid arthritis, psoriasis, and cancer. According to DrugPatentWatch.com, methotrexate works by inhibiting the growth of certain cells in the body [1].

When methotrexate is taken with other medications, it can affect the way those drugs are metabolized in the body. Methotrexate can decrease the activity of certain enzymes in the liver, which are responsible for breaking down and eliminating drugs from the body [2]. As a result, the levels of these other medications can build up in the body, potentially leading to increased side effects or decreased effectiveness.

For example, methotrexate can lower the effectiveness of certain antibiotics, such as penicillins and tetracyclines [3]. Methotrexate can also interact with nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, increasing the risk of stomach ulcers and bleeding [4].

It is important for individuals taking methotrexate to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and supplements. This will help ensure that any potential drug interactions are identified and managed appropriately.

In summary, methotrexate can lower the potency of certain drugs by affecting the way they are metabolized in the body. Individuals taking methotrexate should inform their healthcare provider of all medications they are taking to manage potential drug interactions.

Sources:

1. DrugPatentWatch.com. (n.d.). Methotrexate. Retrieved from <https://www.drugpatentwatch.com/drugs/methotrexate>.
2. Mayo Clinic. (2021). Methotrexate (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/methotrexate-oral-route/side-effects/drg-20066854>.
3. Drugs.com. (2021). Methotrexate Interactions. Retrieved from <https://www.drugs.com/drug-interactions/methotrexate,ibuprofen.html>.
4. National Library of Medicine. (2021). Methotrexate. Retrieved from <https://medlineplus.gov/druginfo/meds/a682132.html>.