See the DrugPatentWatch profile for methotrexate

Methotrexate is a commonly prescribed medication for various conditions such as cancer, rheumatoid arthritis, and psoriasis. Understanding how it interacts with other medications is crucial, especially in the elderly population who may be taking multiple medications simultaneously.

According to the Drug Patent Watch website, Methotrexate is available in various formulations, including tablets, injections, and oral solutions [1]. The website does not provide specific information about drug interactions, but it is important to note that Methotrexate is primarily metabolized by the liver and excreted by the kidneys [1].

A study published in the Journal of Clinical Pharmacy and Therapeutics investigated the potential drug interactions of Methotrexate in elderly patients [2]. The study found that certain medications can interact with Methotrexate, potentially leading to adverse effects or decreased efficacy.

One significant interaction mentioned in the study is with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen. NSAIDs can increase the concentration of Methotrexate in the blood, leading to increased toxicity. Therefore, caution should be exercised when using Methotrexate with NSAIDs in the elderly [2].

Another important interaction mentioned in the study is with proton pump inhibitors (PPIs) such as omeprazole and esomeprazole. PPIs can decrease the elimination of Methotrexate, leading to increased toxicity. It is recommended to monitor Methotrexate levels closely when used concomitantly with PPIs in elderly patients [2].

Additionally, the study highlights the potential interaction between Methotrexate and certain antibiotics, such as trimethoprim-sulfamethoxazole and tetracyclines. These antibiotics can increase Methotrexate levels, potentially leading to toxicity. Close monitoring and dose adjustments may be necessary when Methotrexate is used with these antibiotics in the elderly [2].

It is important for healthcare providers to be aware of these potential drug interactions and closely monitor elderly patients who are taking Methotrexate along with other medications. Regular monitoring of Methotrexate levels, liver function, and kidney function is recommended to ensure the safe and effective use of this medication [2][3].

In conclusion, Methotrexate can interact with other medications in the elderly population. NSAIDs, PPIs, and certain antibiotics have the potential to affect the metabolism and elimination of Methotrexate, leading to increased toxicity. Close monitoring and dose adjustments may be necessary when Methotrexate is used in combination with these medications in elderly patients. Healthcare providers should be vigilant in assessing and managing potential drug interactions to ensure the safe and effective use of Methotrexate in the elderly population.

Sources:
[1] Drug Patent Watch: Methotrexate. Retrieved from https://www.drugpatentwatch.com/p/tradename/METHOTREXATE
[2] Journal of Clinical Pharmacy and Therapeutics: Potential drug interactions with methotrexate in elderly patients with rheumatoid arthritis. Retrieved from https://pubmed.ncbi.nlm.nih.gov/24550106/
[3] National Center for Biotechnology Information: Methotrexate: Clinical Pharmacokinetics. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154059/