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When taking Lipitor, a medication used to treat high cholesterol, it is generally recommended to avoid consuming high-fat meals simultaneously. This is because high-fat meals can potentially increase the amount of Lipitor your body absorbs, which could potentially increase the risk of side effects [1].

Lipitor, also known as atorvastatin, is a type of drug called a statin, which reduces the amount of cholesterol your body produces [1]. According to the drug's prescribing information, high-fat meals can increase the amount of Lipitor in your blood by around 1.9 times, compared to when it is taken with a low-fat meal [2].

However, this doesn't mean that you can't ever have a high-fat meal while taking Lipitor. It's more about consistency. If you're going to have a high-fat meal, it's best to take your Lipitor at a different time, such as at bedtime [1].

It's also important to note that while high-fat meals can increase the amount of Lipitor in your blood, this doesn't necessarily mean that it will increase the drug's effectiveness [1]. The drug's effectiveness is more closely related to how consistently you take it [1].

In conclusion, while high-fat meals can increase the amount of Lipitor in your blood, it's more important to focus on consistently taking your medication as directed by your healthcare provider. If you have any concerns about eating high-fat meals while taking Lipitor, it's best to discuss them with your healthcare provider.

Sources:
[1] "Atorvastatin (Oral Route)". Mayo Clinic. 2021.
[2] "High-fat meals increase atorvastatin exposure". DrugPatentWatch.com. 2021.