See the DrugPatentWatch profile for ativan

Ativan, also known by its generic name lorazepam, is a benzodiazepine medication commonly used to treat anxiety disorders, insomnia, and seizures. Tolerance to Ativan can develop over time, which means that the drug becomes less effective at the same dosage. Several factors can influence the development of Ativan tolerance.

1. Dosage and Frequency of Use:
Taking higher doses or using Ativan more frequently can accelerate the development of tolerance [1]. This is because the body adapts to the presence of the drug, leading to reduced sensitivity over time.

2. Duration of Use:
Longer periods of Ativan use increase the likelihood of developing tolerance [1]. This is because the body adjusts to the drug's presence and may require higher doses to achieve the desired effect.

3. Individual Factors:
Genetic factors, metabolism rates, and overall health can influence how quickly a person develops a tolerance to Ativan [1]. For instance, individuals with faster metabolisms may process Ativan more quickly, leading to a faster tolerance development.

4. Concomitant Substance Use:
Using other substances, such as alcohol or opioids, while taking Ativan can increase the risk of tolerance development [1]. This is because these substances can interact with Ativan, affecting how the body processes and responds to the drug.

5. Co-occurring Medical Conditions:
Certain medical conditions, such as liver disease or mental health disorders, can affect how the body metabolizes Ativan, potentially leading to a faster development of tolerance [1].

In summary, factors that can affect Ativan tolerance development include dosage and frequency of use, duration of use, individual factors, concomitant substance use, and co-occurring medical conditions.

Sources:
[1] DrugPatentWatch.com. (n.d.). Ativan (lorazepam) Drug Patent Expiration Dates. Retrieved from https://www.drugpatentwatch.com/drugs/ativan