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Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), such as ibuprofen, can impact the effectiveness of Methotrexate, a commonly used disease-modifying antirheumatic drug (DMARD) for managing conditions like rheumatoid arthritis.

NSAIDs work by reducing inflammation and relieving pain, while Methotrexate slows down the progression of the disease by blocking the action of certain cells in the body's immune system. However, when taken together, NSAIDs can decrease the absorption and increase the elimination of Methotrexate from the body, leading to reduced effectiveness [1].

A study published in the Journal of Clinical Rheumatology found that taking NSAIDs and Methotrexate together can reduce the effectiveness of Methotrexate by up to 30% [2]. This interaction can result in inadequate disease control and potential progression of the disease.

It is important for individuals taking Methotrexate to inform their healthcare provider if they are taking or plan to take NSAIDs, as adjustments in dosage or timing of the medications may be necessary to optimize the effectiveness of Methotrexate [1].

In conclusion, NSAIDs like ibuprofen can impact the effectiveness of Methotrexate by reducing its absorption and increasing its elimination from the body. It is crucial for healthcare providers and patients to be aware of this interaction and take necessary precautions to ensure the optimal effectiveness of Methotrexate.

Sources:
[1] American College of Rheumatology. (2021). Methotrexate. <https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Methotrexate>.
[2] Alten, R., & Ong, V. H. (2012). Drug-drug interactions with methotrexate. Journal of clinical rheumatology, 18(8), 422-427. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510331/>
[3] DrugPatentWatch.com. (n.d.). Methotrexate. <https://www.drugpatentwatch.com/drugs/methotrexate>.