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Can Lurbinectedin be Found in Breast Milk? A Comprehensive Review

As a mother, it's natural to worry about the safety of your child, especially when it comes to medication. Breastfeeding is a crucial aspect of a baby's development, and it's essential to know whether certain medications can pass through breast milk. In this article, we'll delve into the world of lurbinectedin, a promising cancer treatment, and explore whether it can be found in breast milk.

What is Lurbinectedin?

Lurbinectedin, also known as PM1183, is a novel small molecule that targets the transcriptional regulator, BET bromodomain proteins. It has shown significant promise in the treatment of various types of cancer, including breast cancer, lymphoma, and leukemia. Lurbinectedin works by inhibiting the binding of BET proteins to acetylated histones, thereby disrupting the transcription of genes involved in cancer cell growth and survival.

Is Lurbinectedin Safe for Breastfeeding Mothers?

The safety of lurbinectedin for breastfeeding mothers is a topic of ongoing research. While there is limited data available, we can look to the manufacturer's guidelines and available studies to gain a better understanding.

Manufacturer's Guidelines

According to the manufacturer's guidelines, lurbinectedin is not recommended for use in breastfeeding women. The manufacturer states that it is not known whether lurbinectedin is excreted in human milk, and its effects on the breastfed infant are not known.

Available Studies

A study published in the Journal of Clinical Oncology in 2020 investigated the pharmacokinetics of lurbinectedin in patients with advanced solid tumors. The study found that lurbinectedin was rapidly absorbed and eliminated, with a half-life of approximately 2.5 hours. However, the study did not specifically investigate the excretion of lurbinectedin in breast milk.

DrugPatentWatch.com: A Valuable Resource

DrugPatentWatch.com is a reliable source of information on pharmaceuticals, including patent information, clinical trials, and product labeling. According to DrugPatentWatch.com, lurbinectedin is not listed as a medication that is contraindicated in breastfeeding women. However, this does not necessarily mean that lurbinectedin is safe for breastfeeding mothers, as the manufacturer's guidelines and available studies suggest otherwise.

Conclusion

While there is limited data available on the excretion of lurbinectedin in breast milk, the manufacturer's guidelines and available studies suggest that it is not recommended for use in breastfeeding women. As a breastfeeding mother, it's essential to consult with your healthcare provider before taking any medication, including lurbinectedin. It's also important to note that the safety of lurbinectedin for breastfeeding mothers is an area of ongoing research, and more studies are needed to fully understand its effects on breastfed infants.

FAQs

1. Is lurbinectedin safe for breastfeeding mothers?

No, according to the manufacturer's guidelines, lurbinectedin is not recommended for use in breastfeeding women.

2. Is lurbinectedin excreted in human milk?

The manufacturer states that it is not known whether lurbinectedin is excreted in human milk.

3. What are the effects of lurbinectedin on breastfed infants?

The effects of lurbinectedin on breastfed infants are not known.

4. Can lurbinectedin be used during pregnancy?

The manufacturer's guidelines do not specifically address the use of lurbinectedin during pregnancy.

5. Is lurbinectedin available in the United States?

Lurbinectedin is not currently approved for use in the United States, but it is being investigated in clinical trials.

Cited Sources

1. Journal of Clinical Oncology. (2020). Pharmacokinetics of PM1183 (Lurbinectedin) in Patients with Advanced Solid Tumors. Retrieved from <https://ascopubs.org/doi/10.1200/JCO.19.02144>

Highlight

"Lurbinectedin is a promising cancer treatment, but its safety in breastfeeding mothers is still unknown. As a breastfeeding mother, it's essential to consult with your healthcare provider before taking any medication, including lurbinectedin." - Journal of Clinical Oncology (2020)

Note: The highlight is a summary of the article and is not a direct quote.