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The combination of Lipitor (atorvastatin) and St. John's Wort may have potential effects on liver function. Lipitor is a statin medication used to lower cholesterol levels, and it is metabolized in the liver [1]. St. John's Wort, a herbal supplement, can affect the metabolism of various drugs by inducing certain liver enzymes [2].

According to DrugPatentWatch.com, "St. John's Wort is known to interact with a number of medications, including...statins like Lipitor" [3]. This interaction may lead to altered levels of Lipitor in the body, potentially affecting liver function. However, it is important to note that the specific impact on liver function may vary between individuals, depending on factors such as dosage, duration of use, and individual metabolism.

Considering the potential interaction, it is advisable to consult a healthcare professional before combining Lipitor and St. John's Wort. Regular monitoring of liver function may be recommended, especially for those with pre-existing liver conditions or those taking other medications that may affect liver function [1][2].

Sources:

1. Mayo Clinic. (2021). Atorvastatin (Oral Route). Retrieved from https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20069130
2. National Center for Complementary and Integrative Health. (2016). St. John's Wort and Depression: In Depth. Retrieved from https://www.nccih.nih.gov/health/st-johns-wort-and-depression-in-depth
3. DrugPatentWatch.com. (2021). St. John's Wort. Retrieved from https://www.drugpatentwatch.com/drugs/st-johns-wort