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A low-fat diet can potentially enhance the effectiveness of Lipitor, a medication commonly prescribed to manage high cholesterol levels. Lipitor, also known as atorvastatin, is a statin drug that lowers cholesterol by reducing the production of cholesterol in the body and increasing the removal of low-density lipoprotein (LDL), or "bad" cholesterol, from the bloodstream [1].

A low-fat diet can contribute to the management of high cholesterol by reducing the overall intake of dietary fats, particularly saturated and trans fats, which are known to increase cholesterol levels [2]. By following a low-fat diet, patients can help create an environment that allows Lipitor to work more effectively in reducing cholesterol levels and minimizing the risk of cardiovascular diseases [3].

It is important to note that a low-fat diet should be accompanied by other heart-healthy lifestyle changes, such as regular exercise, limiting alcohol consumption, and avoiding tobacco products [4]. Additionally, patients should consult with their healthcare providers before making any significant changes to their diet or starting a new medication regimen [5].

Sources:

1. [Lipitor (atorvastatin calcium)](https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/20267s062,20268s046,20269s039lbl.pdf)
2. [Dietary Fats - American Heart Association](https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/fats/dietary-fats)
3. [How to Lower Your Cholesterol - Mayo Clinic](https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/lower-cholesterol/art-20045935)
4. [How to Lower Cholesterol Naturally - Healthline](https://www.healthline.com/nutrition/lower-cholesterol-naturally)
5. [Low-Fat Diet - MedlinePlus](https://medlineplus.gov/lowfatdiet.html)