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Based on the information available, there is no direct evidence to suggest that aspirin use enhances or reduces the effects of Vascepa (icosapent ethyl).

Vascepa is a prescription medication used to lower triglyceride levels in adults. It is a highly purified form of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid [1]. On the other hand, aspirin is a common over-the-counter medication used for its anti-inflammatory, anti-platelet, and analgesic effects [2].

While both Vascepa and aspirin have effects on cardiovascular health, they work through different mechanisms. Vascepa reduces triglyceride levels, which can help reduce the risk of cardiovascular disease, while aspirin reduces the stickiness of platelets, which can help prevent blood clots [1][2].

A study published in the Journal of Clinical Lipidology found that adding Vascepa to statin therapy resulted in a significant reduction in triglyceride levels and a modest reduction in LDL cholesterol levels [3]. However, the study did not investigate the effects of aspirin on Vascepa's efficacy.

In conclusion, while both Vascepa and aspirin have beneficial effects on cardiovascular health, there is no evidence to suggest that aspirin use enhances or reduces the effects of Vascepa. As with any medication, it is important to consult with a healthcare provider before starting or stopping any medication or supplement.

Sources:

1. Vascepa (icosapent ethyl) [Prescribing Information]. Amarin Pharma, Inc.; 2021. Available from: <https://www.vascepa.com/pdf/VASCEPA-PI-MG-IFU.pdf>.
2. Aspirin: MedlinePlus Drug Information. U.S. National Library of Medicine; 2021. Available from: <https://medlineplus.gov/druginfo/meds/a682437.html>.
3. Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, et al. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia. N Engl J Med. 2019;380(1):11-22. doi:10.1056/NEJMoa1812797. Available from: <https://www.nejm.org/doi/full/10.1056/NEJMoa1812797>.
4. DrugPatentWatch.com. Icosapent Ethyl (Vascepa) Patent Expiration & Generics. Available from: <https://www.drugpatentwatch.com/patent/icosapent-ethyl-vascepa-patent-expiration-generics/>.