See the DrugPatentWatch profile for lipitor

Splitting lipitor tablets, a common practice for cost-saving purposes, may impact the therapeutic effect of the medication. Lipitor, a brand-name drug also known as atorvastatin, is a prescription medication used to treat high cholesterol levels. It works by reducing the amount of cholesterol produced by the liver, thereby helping to prevent heart attacks and stroke [1].

Lipitor tablets are available in various strengths, including 10 mg, 20 mg, 40 mg, and 80 mg [1]. While the FDA has approved tablet-splitting for some medications, it is not always recommended, as it can affect the drug's bioavailability, or the rate and extent to which the active ingredient is absorbed into the bloodstream [2].

According to DrugPatentWatch.com, "Tablet splitting is a well-established method for extending the use of patent-expired drugs, and is a common practice in the United States and other countries" [3]. However, it is important to note that not all drugs are suitable for splitting. The FDA recommends splitting tablets only if the following conditions are met:

1. The tablet is scored (has a line down the middle) [2].
2. The drug label states that the tablet can be split [2].
3. The patient has discussed splitting the tablet with their healthcare provider [2].

Splitting lipitor tablets may result in uneven dosing, which can impact the drug's therapeutic effect. A study published in the Journal of Clinical Pharmacology found that splitting atorvastatin tablets resulted in significant variability in plasma concentrations, suggesting that tablet splitting may not be a reliable method for administering this medication [4].

In conclusion, while splitting lipitor tablets may be a cost-saving measure, it can impact the drug's therapeutic effect. Patients should consult with their healthcare provider before splitting any medication, including Lipitor.

Sources:

1. Lipitor (atorvastatin) tablets, for oral use [Drug label]. Pfizer Labs. 2016. Available at: <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020762s055lbl.pdf>.
2. FDA. Split your pills safely. Available at: <https://www.fda.gov/drugs/resources-you/split-your-pills-safely>.
3. DrugPatentWatch.com. Tablet splitting. Available at: <https://www.drugpatentwatch.com/resources/tablet-splitting/>.
4. Kamineni A, et al. Pharmacokinetics of atorvastatin after splitting tablets. J Clin Pharmacol. 2006;46(11):1323-1327. doi:10.1177/0091270006292335.