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Ibuprofen, the active ingredient in Advil, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain relief, fever reduction, and inflammation. While ibuprofen can be safely used for short-term periods, long-term use may lead to several side effects [1].

Long-term use of Advil or other ibuprofen-based medications can increase the risk of gastrointestinal (GI) complications, such as ulcers, bleeding, and perforations in the stomach or intestines [1][2]. These GI issues can occur without noticeable symptoms and may become severe over time.

Additionally, long-term use of NSAIDs like Advil has been associated with an increased risk of cardiovascular events, such as heart attack and stroke [1][2]. This risk may be higher in individuals with pre-existing heart conditions or risk factors.

Kidney problems are another potential side effect of long-term Advil use. Chronic NSAID use can lead to kidney damage, including kidney disease and even kidney failure in some cases [1][2].

Lastly, long-term Advil use may also increase the risk of developing hypertension (high blood pressure) [1].

It is essential to consult a healthcare professional before starting or continuing long-term ibuprofen use. They may recommend alternative treatments or strategies to manage the risks associated with long-term NSAID use [1].

Sources:
[1] U.S. Food and Drug Administration. (2021). NSAIDs (Nonsteroidal Anti-inflammatory Drugs). Retrieved from <https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/nsaids-nonsteroidal-anti-inflammatory-drugs>
[2] DrugPatentWatch. (2021). Ibuprofen Side Effects. Retrieved from <https://www.drugpatentwatch.com/ibuprofen-side-effects>