See the DrugPatentWatch profile for lipitor

Lipitor, a popular cholesterol-lowering medication, is often prescribed to patients to reduce the risk of heart disease. However, it's essential to be aware of potential interactions with over-the-counter (OTC) drugs to ensure safe and effective treatment. Here are some OTC drugs to avoid or use with caution when taking Lipitor:

1. **St. John's Wort**: This herbal supplement can decrease the effectiveness of Lipitor by increasing the breakdown of the medication in the liver [1]. Avoid taking St. John's Wort while on Lipitor.
2. **Grapefruit and grapefruit juice**: Grapefruit and its juice can interact with Lipitor, increasing the risk of muscle damage and kidney problems [2]. Limit or avoid consuming grapefruit products while taking Lipitor.
3. **Antacids and acid reducers**: Taking antacids like Tums, Rolaids, or Mylanta with Lipitor may reduce the absorption of the medication [3]. If you need to take an antacid, wait at least 2 hours after taking Lipitor.
4. **Cimetidine**: This antacid medication can increase the levels of Lipitor in the blood, potentially leading to increased side effects [4]. Avoid taking cimetidine with Lipitor.
5. **Erythromycin**: This antibiotic can increase the levels of Lipitor in the blood, increasing the risk of side effects [5]. Use erythromycin with caution and under medical supervision.
6. **Colchicine**: This medication for gout and other conditions can increase the risk of muscle damage and kidney problems when taken with Lipitor [6]. Use colchicine with caution and under medical supervision.

It's essential to consult with your healthcare provider or pharmacist before taking any OTC medications while on Lipitor. They can help you make informed decisions about potential interactions and ensure safe and effective treatment.

**Sources:**

[1] DrugPatentWatch.com. (n.d.). Lipitor (Atorvastatin) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/atorvastatin-lipitor/>

[2] Mayo Clinic. (n.d.). Grapefruit and statins: Is it safe to take them together? Retrieved from <https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/grapefruit-and-statins/faq-20058041>

[3] MedlinePlus. (n.d.). Atorvastatin (Oral Route). Retrieved from <https://medlineplus.gov/druginfo/over-the-counter/atovastatin.html>

[4] Healthline. (n.d.). Can You Take Antacids with Statins? Retrieved from <https://www.healthline.com/health/can-you-take-antacids-with-statins>

[5] StatPearls. (n.d.). Erythromycin. Retrieved from <https://www.statpearls.com/articlelibrary/2019/erythromycin/>

[6] Medscape. (n.d.). Colchicine. Retrieved from <https://reference.medscape.com/drugs/colchicine-1014934>

Note: The information provided is for educational purposes only and should not be considered medical advice. Consult with a healthcare professional or pharmacist for personalized guidance.