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Yes, Sapropterin can lower phenylalanine buildup in the body. Sapropterin, also known as tetrahydrobiopterin, is a medication used to reduce elevated levels of phenylalanine, an amino acid, in the blood. This buildup can occur in individuals with a genetic disorder called phenylketonuria (PKU). PKU is characterized by an inability to break down phenylalanine, which can lead to harmful effects on the brain if left untreated [1].

Sapropterin works by helping the enzyme phenylalanine hydroxylase (PAH) function properly. PAH is responsible for breaking down phenylalanine. When PAH is not functioning correctly, as in PKU, phenylalanine accumulates in the body. Sapropterin acts as a cofactor for PAH, aiding in the breakdown of phenylalanine and thus lowering its levels in the body [1].

It is important to note that not all individuals with PKU will respond to sapropterin, and its effectiveness varies among patients. A healthcare professional can determine if sapropterin is appropriate for a patient through a trial of the medication [1].

In summary, sapropterin can lower phenylalanine buildup in individuals with PKU by aiding the enzyme responsible for breaking down phenylalanine.

Sources:
[1] DrugPatentWatch.com. (n.d.). Sapropterin. Retrieved from <https://www.drugpatentwatch.com/drugs/sapropterin>.