See the DrugPatentWatch profile for lipitor

Based on the information available, there appears to be a link between Lipitor (atorvastatin) dosage and liver enzyme levels. Lipitor is a statin medication used to treat high cholesterol, and like other statins, it has been associated with increased liver enzyme levels in some patients [1].

A study published in the Journal of Clinical Pharmacology found that higher doses of atorvastatin were associated with greater increases in liver enzyme levels, particularly alanine aminotransferase (ALT) and aspartate aminotransferase (AST) [2]. However, it is important to note that these increases were generally small and not associated with any clinically significant liver damage.

The prescribing information for Lipitor states that "increases in serum transaminases (AST and ALT) have been reported with HMG-CoA reductase inhibitors, including atorvastatin. These increases were usually transient and were not associated with jaundice or other clinical signs or symptoms. Persistent increases (to more than 3 times the upper limit of normal) occurred in approximately 0.7% of patients treated with Lipitor in clinical trials" [3].

It is recommended that liver enzyme levels be monitored in patients taking Lipitor, particularly those taking higher doses or those with pre-existing liver disease [1]. Patients should speak with their healthcare provider if they have any concerns about their liver enzyme levels or their Lipitor dosage.

In summary, there is a link between Lipitor dose and liver enzyme levels, with higher doses associated with greater increases in liver enzymes. However, these increases are generally small and not associated with clinically significant liver damage.

Sources:

1. Drugs.com. (2022). Lipitor. Retrieved from <https://www.drugs.com/lipitor.html>
2. Kostapanos, M. S., & Filioussi, K. (2012). Effect of atorvastatin on liver enzymes: a systematic review and meta-analysis. Journal of clinical pharmacy and therapeutics, 37(3), 255-262.
3. Pfizer. (2016). Lipitor (atorvastatin calcium) tablets, for oral use. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/20267s123,20267s124,20267s125lbl.pdf>
4. DrugPatentWatch.com. (n.d.). Lipitor (atorvastatin) Patents. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>