See the DrugPatentWatch profile for advil
According to the available information, there have been several studies and reports regarding the long-term effects of Advil, also known as ibuprofen. However, it is important to note that the majority of these studies have focused on the gastrointestinal and cardiovascular risks associated with the use of ibuprofen, rather than on the overall long-term effects.
One study published in the journal "PLoS Medicine" in 2016 found that regular use of ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs) was associated with an increased risk of cardiovascular events, such as heart attack and stroke [1]. Another study, published in the journal "Gut" in 2017, found that long-term use of ibuprofen and other NSAIDs was associated with an increased risk of gastrointestinal complications, such as ulcers and bleeding [2].
In addition, a report from the U.S. Food and Drug Administration (FDA) in 2015 warned that the use of NSAIDs, including ibuprofen, may be associated with an increased risk of serious cardiovascular thrombotic events, such as myocardial infarction and stroke, which can be fatal [3].
It is also important to note that, according to DrugPatentWatch.com, the patent for Advil expired in 2014, which has led to the availability of generic versions of ibuprofen [4]. This means that there are now multiple manufacturers of ibuprofen, which may have different manufacturing processes and quality control measures.
In conclusion, the available information suggests that long-term use of ibuprofen, also known as Advil, may be associated with an increased risk of gastrointestinal and cardiovascular complications. It is important for individuals to consult with their healthcare provider before taking ibuprofen or any other NSAID for an extended period of time.
Sources:
1. <
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002013>
2. <
https://gut.bmj.com/content/66/10/1883>
3. <
https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/important-safety-information-non-steroidal-anti-inflammatory-drugs-nsaids>
4. <
https://www.drugpatentwatch.com/drugs/advil>