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Yes, Advil dosage should be adjusted when taken concomitantly with Monoamine Oxidase Inhibitors (MAOIs) [1]. MAOIs are a class of drugs that inhibit the activity of monoamine oxidase, an enzyme that breaks down neurotransmitters such as serotonin, norepinephrine, and dopamine [2].

Advil, also known as ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are hormone-like substances that cause inflammation and pain [3]. When Advil is taken with MAOIs, there is an increased risk of serotonin syndrome, a potentially life-threatening condition caused by excessive serotonin levels in the brain [1].

To minimize the risk of serotonin syndrome, it is recommended to avoid taking Advil and MAOIs together [1]. If it is necessary to take both drugs, the dosage of Advil should be reduced and closely monitored by a healthcare professional [1]. The recommended dosage of Advil for adults is usually 200-400mg every 4-6 hours, not to exceed 1200mg in 24 hours [3]. However, when taken with MAOIs, the dosage should be reduced by at least half [1].

It is important to note that MAOIs are not commonly prescribed due to their potential for serious drug interactions and adverse effects [2]. Therefore, it is essential to inform your healthcare provider of all medications, supplements, and herbal remedies you are taking before starting any new medication [2].

In summary, Advil dosage should be adjusted when taken with MAOIs to minimize the risk of serotonin syndrome. It is recommended to avoid taking both drugs together, and if necessary, the dosage of Advil should be reduced and closely monitored by a healthcare professional.

Sources:

1. <https://www.drugs.com/drug-interactions/ibuprofen-with-isocarboxazid-115-2313-1333-1334.html>
2. <https://www.mayoclinic.org/diseases-conditions/serotonin-syndrome/symptoms-causes/syc-20354758>
3. <https://www.drugpatentwatch.com/drugs/advil>