See the DrugPatentWatch profile for tigecycline

Tigecycline is a broad-spectrum antibiotic, often used to treat various bacterial infections, such as skin infections, intra-abdominal infections, and community-acquired pneumonia [1]. According to the prescribing information provided by the Food and Drug Administration (FDA), tigecycline has been associated with elevations in liver enzymes, specifically aspartate aminotransferase (AST) and alanine aminotransferase (ALT) [2].

These enzymes, AST and ALT, are commonly found in hepatocytes (liver cells) and are used as biomarkers for liver function. When liver cells are damaged or inflamed, these enzymes are released into the bloodstream, leading to increased levels that can be detected in blood tests [3].

In summary, tigecycline has been linked to elevated levels of the liver enzymes AST and ALT, which can indicate potential liver damage or inflammation [2]. Healthcare professionals should monitor liver function in patients receiving tigecycline treatment, particularly during prolonged therapy [2].

Sources:
[1] Drugs.com. (2021). Tigecycline: Uses, Dosage, Side Effects, Interactions, Warning. Retrieved from <https://www.drugs.com/tigecycline.html>
[2] U.S. Food and Drug Administration. (2010). Tygacil (tigecycline) for injection, for intravenous use. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021867s010lbl.pdf>
[3] National Institute of Diabetes and Digestive and Kidney Diseases. (2019). Liver Function Tests. Retrieved from <https://www.niddk.nih.gov/health-information/blood-test/liver-function-tests>