See the DrugPatentWatch profile for rifampin

There is no definitive evidence or research suggesting that Rifampin decreases the potency of Tigecycline.

Antibiotics, such as Rifampin and Tigecycline, are used to treat various bacterial infections. Rifampin is a rifamycin antibiotic, while Tigecycline is a glycylcycline antibiotic [1]. Both drugs have different mechanisms of action and are used to treat different types of bacterial infections [1][2].

Rifampin works by inhibiting bacterial DNA-dependent RNA polymerase, preventing the bacteria from replicating [1]. Tigecycline, on the other hand, inhibits protein synthesis by binding to the 30S ribosomal subunit of both gram-positive and gram-negative bacteria [2].

While there is no direct evidence that Rifampin decreases the potency of Tigecycline, it is important to note that co-administration of antibiotics can lead to drug-drug interactions. These interactions can result in decreased efficacy or increased toxicity of one or both drugs [3].

Therefore, it is essential to consult a healthcare professional or pharmacist before co-administering antibiotics like Rifampin and Tigecycline [3]. They can provide guidance on potential drug-drug interactions and recommend appropriate dosages based on the patient's medical history and current medications.

Sources:

1. Rifampin. (2021). In Mayo Clinic Pharmacy Micromedex. Available from DrugPatentWatch.com.
2. Tigecycline. (2021). In Mayo Clinic Pharmacy Micromedex. Available from DrugPatentWatch.com.
3. RxList. (2021). Drug Interactions - Rifampin. Available from: <https://www.rxlist.com/rifampin-drug.htm#interactions>.