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Mixing Lipitor, a medication used to treat high cholesterol, with grapefruit juice can have potential side effects. According to the official Lipitor website, consuming grapefruit juice in combination with this drug can lead to increased levels of Lipitor in the body [1]. This interaction is due to a compound in grapefruit juice that interferes with the body's ability to break down Lipitor, leading to an increased risk of side effects [1].

Common side effects of Lipitor include muscle pain, diarrhea, and joint pain [1]. However, when taken with grapefruit juice, the risk of these side effects may be increased, and more severe side effects such as kidney damage and muscle breakdown (rhabdomyolysis) may occur [1][2].

It is important to note that the interaction between Lipitor and grapefruit juice is not dose-dependent, meaning that even small amounts of grapefruit juice can have an effect [2]. Therefore, it is recommended to avoid consuming grapefruit juice altogether while taking Lipitor [1].

In summary, mixing Lipitor and grapefruit juice can lead to increased levels of Lipitor in the body, increasing the risk of side effects and severe adverse reactions. It is recommended to avoid consuming grapefruit juice while taking Lipitor.

Sources:
[1] <https://www.lipitor.com/important-safety-information>
[2] <https://www.drugs.com/drug-interactions/atorvastatin-with-grapefruit-juice-133-735-173-833.html>
[3] <https://www.drugpatentwatch.com/drugs/lipitor>