See the DrugPatentWatch profile for lipitor

Based on the available information, there is no direct evidence that any specific supplement decreases the potency of Lipitor (atorvastatin), a medication used to treat high cholesterol levels. However, it is important to note that certain supplements can interact with Lipitor and affect its efficacy or increase the risk of side effects.

According to the National Center for Biotechnology Information (NCBI) [${2}], some supplements, such as red yeast rice, contain monacolins, which are structurally similar to statins and can increase the risk of myopathy and rhabdomyolysis when taken with Lipitor.

Additionally, the Office of Dietary Supplements (ODS) [${3}] states that vitamin D supplements can interact with cholesterol-lowering drugs like Lipitor, potentially increasing the risk of muscle damage. However, it is important to note that vitamin D supplements do not directly decrease Lipitor's potency.

In summary, while there is no direct evidence that any supplement decreases Lipitor's potency, certain supplements, such as red yeast rice and vitamin D, can interact with Lipitor and increase the risk of side effects. It is always recommended to consult with a healthcare provider before starting any new supplement regimen while taking Lipitor.

Sources:

* [Lipitor Patent Information](https://www.drugpatentwatch.com/p/tradename/LIPITOR)
* [NCBI - Statins and Red Yeast Rice: Interactions, Safety, and Efficacy](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136538/)
* [ODS - Vitamin D Fact Sheet for Health Professionals](https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/)