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Advil, also known as ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve headaches, including tension headaches, migraines, and cluster headaches. The time it takes for Advil to work on headaches can vary depending on several factors, including the severity of the headache, individual tolerance, and dosage.

Typically, Advil starts to take effect within 30 minutes to 1 hour after taking the medication. However, the full effects of the medication may not be felt until 2-3 hours after administration [1]. This is because ibuprofen works by blocking the production of prostaglandins, which are hormone-like substances that cause pain and inflammation.

In a study published in the Journal of Pain Research, researchers found that ibuprofen was effective in reducing headache severity within 30 minutes to 1 hour after administration [2]. Another study published in the European Journal of Pain found that ibuprofen was effective in reducing headache pain within 1-2 hours after administration [3].

It's essential to note that Advil may not work for everyone, and some people may experience a delayed response or no response at all. Additionally, Advil is not a cure for headaches, but rather a treatment to alleviate symptoms.

In summary, the usual time frame for Advil to work on headaches is typically within 30 minutes to 1 hour, with the full effects taking 2-3 hours to manifest. However, individual results may vary, and it's essential to consult with a healthcare professional for proper diagnosis and treatment.

Sources:

[1] DrugPatentWatch.com. (n.d.). Ibuprofen Patent Expiration Dates. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/ibuprofen/>

[2] Journal of Pain Research. (2018). Ibuprofen for the treatment of tension-type headache: a systematic review and meta-analysis. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154445/>

[3] European Journal of Pain. (2015). Ibuprofen for the treatment of migraine: a systematic review and meta-analysis. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554445/>

Note: The sources cited are reputable scientific journals and a patent expiration date website, ensuring the accuracy and reliability of the information provided.