See the DrugPatentWatch profile for methotrexate

Methotrexate is a commonly prescribed drug for various conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer [1]. However, its use in elderly patients can have a significant impact on their kidneys.

Methotrexate is primarily excreted by the kidneys, and its clearance decreases with age due to the natural decline in renal function that occurs as people get older [2]. This can lead to an accumulation of the drug in the body, increasing the risk of toxicity.

One of the most common kidney-related side effects of methotrexate is acute kidney injury (AKI), which can occur in up to 30% of elderly patients taking the drug [3]. AKI is characterized by a sudden decrease in kidney function, which can lead to a buildup of waste products in the body and potentially life-threatening complications.

In addition to AKI, methotrexate can also cause chronic kidney disease (CKD) in elderly patients [4]. CKD is a progressive loss of kidney function over time, which can ultimately lead to kidney failure.

To minimize the risk of kidney-related side effects in elderly patients taking methotrexate, healthcare providers may need to adjust the dosage based on the patient's renal function [5]. Close monitoring of kidney function is also essential, particularly during the first few weeks of treatment, when the risk of toxicity is highest.

In summary, methotrexate can have a significant impact on the kidneys of elderly patients, increasing the risk of acute and chronic kidney injury. Close monitoring and dosage adjustment are crucial to minimize these risks.

Sources:

1. Methotrexate. Drugs.com. <https://www.drugs.com/methotrexate.html>.
2. Methotrexate. Mayo Clinic. <https://www.mayoclinic.org/drugs-supplements/methotrexate-oral-route/side-effects/drg-20063430>.
3. Methotrexate-induced acute kidney injury: a systematic review. Renal Failure. 2015;37(2):255-263. <https://www.ncbi.nlm.nih.gov/pubmed/25573339>.
4. Methotrexate-induced chronic kidney disease: a case report and review of the literature. Clinical Kidney Journal. 2015;8(3):263-266. <https://academic.oup.com/ckj/article/8/3/263/2538347>.
5. Methotrexate. DrugPatentWatch. <https://www.drugpatentwatch.com/drugs/methotrexate>.