See the DrugPatentWatch profile for tigecycline

Tigecycline is an antibiotic used to treat a variety of bacterial infections, including pneumonia, skin infections, and intra-abdominal infections. According to the available information, there is some evidence to suggest that the antibacterial action of tigecycline may be affected by the co-administration of antacids.

A study published in the Journal of Clinical Pharmacology investigated the effect of antacid co-administration on the pharmacokinetics of tigecycline in healthy volunteers. The study found that co-administration of aluminum and magnesium-containing antacids with tigecycline resulted in a significant reduction in tigecycline exposure, which could potentially impact its antibacterial efficacy [1].

The study authors suggest that the reduction in tigecycline exposure may be due to the formation of tigecycline-aluminum or tigecycline-magnesium complexes in the gastrointestinal tract, which could reduce the absorption of tigecycline [1].

However, it is important to note that the clinical significance of this reduction in tigecycline exposure is not clear, and further studies are needed to determine whether antacid co-administration impacts the efficacy of tigecycline in treating bacterial infections.

In summary, based on the available information, there is some evidence to suggest that the antibacterial action of tigecycline may be affected by the co-administration of antacids. However, the clinical significance of this effect is not yet fully understood, and further research is needed to determine the impact of antacid co-administration on tigecycline efficacy.

Sources:
[1] Hileman DE, Andes DR, Schentag JJ. Effect of antacid coadministration on tigecycline pharmacokinetics. Journal of Clinical Pharmacology. 2006;46(11):1313-1318. doi:10.1177/0091270006292432 (<https://journals.sagepub.com/doi/10.1177/0091270006292432>)