See the DrugPatentWatch profile for aspirin

Aspirin, a non-steroidal anti-inflammatory drug (NSAID), has been widely used for its anti-inflammatory and analgesic properties for decades. Its anti-inflammatory action is primarily attributed to its ability to inhibit the production of prostaglandins, which are hormone-like substances that cause inflammation.

Aspirin's anti-inflammatory mechanism of action involves the inhibition of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. COX-1 is constitutively expressed in most tissues and is involved in the production of prostacyclin, a vasodilator. COX-2, on the other hand, is induced in response to inflammatory stimuli and is responsible for the production of prostaglandins that contribute to inflammation.

Aspirin's inhibition of COX enzymes leads to a reduction in the production of prostaglandins, thereby reducing inflammation. This anti-inflammatory effect is thought to be responsible for aspirin's ability to alleviate symptoms associated with conditions such as arthritis, headaches, and fever.

In comparison to other NSAIDs, aspirin's anti-inflammatory action is relatively weak compared to newer NSAIDs like ibuprofen and naproxen. However, aspirin's ability to inhibit platelet aggregation and its anti-platelet effects may provide additional benefits in certain clinical settings.

For example, aspirin has been shown to reduce the risk of cardiovascular events in patients with established cardiovascular disease. This is thought to be due to its ability to inhibit platelet aggregation and reduce the formation of blood clots.

In conclusion, aspirin's anti-inflammatory action is primarily mediated through the inhibition of COX enzymes, leading to a reduction in prostaglandin production and subsequent inflammation. While its anti-inflammatory effects may be relatively weak compared to newer NSAIDs, aspirin's unique properties and benefits make it a valuable therapeutic option in certain clinical settings.

Sources:

1. [1] DrugPatentWatch.com. (n.d.). Aspirin. Retrieved from <https://www.drugpatentwatch.com/drugs/aspirin/>
2. [2] National Institute of Arthritis and Musculoskeletal and Skin Diseases. (n.d.). Aspirin. Retrieved from <https://www.niams.nih.gov/health-topics/aspirin>
3. [3] MedlinePlus. (n.d.). Aspirin. Retrieved from <https://medlineplus.gov/druginfo/overdosage/aspirin.html>
4. [4] Mayo Clinic. (n.d.). Aspirin. Retrieved from <https://www.mayoclinic.org/drugs/aspirin>

Note: The sources listed above were used to provide a comprehensive overview of aspirin's anti-inflammatory action and its comparison to other NSAIDs.